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Antibody-binding proteins are available in purified form, and as biotinylated or peroxidase-labeled (HRP) conjugates for secondary detection in microplate assays, membrane assays, and other laboratory procedures.
A P2Y2 and P2Y4 receptor agonist (EC50s = 0.1 and 0.4 µM, respectively, in calcium mobilization assays); selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = 20 µM); induces the release of mucin-like glycoproteins from rabbit conjunctival goblet cells, as well as reduces desiccation-induced corneal damage in a rabbit model of dry eye disease at 0.1 and 1% w/v
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A prodrug form of 5-ASA; increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM); stimulates fluid transport in rat jejunum (5 mM); improves stool consistency and decreases occult and gross bleeding as well as MPO activity and LTB4 levels in colon tissue in a mouse model of dextran sulfate-induced colitis (150 mg/kg for 8 days); inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L); lowers serum uric acid levels in an oxonic acid-induced mouse model of hyperuricemia (20 mg/kg)
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A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
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A β-lactam antibiotic; active against clinical isolates of S. aureus (MICs = 0.12-0.25 mg/L); decreases vegetation titers in a rat model of S. aureus-induced aortic valve endocarditis at 42.3 mg/kg every six hours
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